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Silence Therapeutics Announces Publication in the Journal of the American Medical Association Highlighting Results From SLN360 Phase 1 Study in Health

Final results have been simultaneously offered now in a late breaker at the American University of Cardiology’s 71st Annual Scientific Session (ACC.22) in Washington, D.C.

LONDON–(Organization WIRE)–Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a leader in the discovery, progress and shipping and delivery of novel brief interfering ribonucleic acid (siRNA) therapeutics for the cure of conditions with substantial unmet clinical will need, these days announced publication of success from the phase 1 APOLLO trial of SLN360, an siRNA concentrating on lipoprotein(a) (“Lp(a)”), in the newest difficulty of the Journal of the American Healthcare Affiliation (JAMA), linked in this article.

Published by the American Health-related Affiliation (AMA), JAMA is the most commonly circulated health-related journal in the globe, with above 55 million write-up sights and downloads every year, and is amongst the most regularly cited healthcare and science journals.

The paper, authored by senior healthcare and scientific specialists from the two Silence and main cardiology facilities, confirmed that SLN360 minimized blood amounts of Lp(a), a essential genetic possibility component for heart illness, by up to 98% in healthier grown ups with elevated Lp(a).

The outcomes have been at the same time offered now in a late breaker at the American School of Cardiology’s 71st Yearly Scientific Session & Expo (ACC.22) in Washington, D.C.

About SLN360

Silence’s wholly owned direct solution candidate, SLN360, is a gene ‘silencing’ remedy – a single that is created to briefly block a precise gene’s message that would in any other case trigger an undesirable impact. In this circumstance, it aims to ‘silence’ LPA, a gene that tells the overall body to make a distinct protein that is only uncovered in Lp(a). By silencing LPA, the ranges of Lp(a) are lowered, which in transform is anticipated to lower the risk of coronary heart illnesses, coronary heart attacks and strokes.

SLN360 is getting examined in the APOLLO scientific trial method. For a lot more data about the APOLLO examine, you should simply click listed here.

About Lipoprotein(a)

Lipoprotein(a), identified as Lp(a) for brief, is a particle produced by the liver, which is made up of cholesterol, fats and proteins. Most folks have some Lp(a) in their human body, but about 1 in 5 people have substantial amounts of Lp(a), because of a precise gene variation in their DNA. Most persons are unaware if they have elevated Lp(a).

Men and women living with elevated Lp(a) have a larger threat of building early coronary heart ailment, coronary heart attacks and strokes. Most typical cholesterol exams do not at the moment involve screening for Lp(a). Current medications that are utilized to reduce other lipid concentrations in the blood do not have a significant result on Lp(a) and are significantly less effective over-all in folks with high amounts of Lp(a).

About Silence Therapeutics

Silence Therapeutics is building a new technology of medicines by harnessing the body’s natural system of RNA interference, or RNAi, to inhibit the expression of unique focus on genes considered to enjoy a function in the pathology of conditions with significant unmet want. Silence’s proprietary mRNAi GOLD™ system can be utilized to generate siRNAs (quick interfering RNAs) that exactly focus on and silence sickness-connected genes in the liver, which represents a considerable chance. Silence’s wholly owned products candidates contain SLN360 created to address the significant and common unmet clinical want in lowering cardiovascular danger in men and women born with superior levels of lipoprotein(a) and SLN124 developed to handle scarce hematological ailments. Silence also maintains ongoing analysis and advancement collaborations with AstraZeneca, Mallinckrodt Prescribed drugs, and Hansoh Pharma, between many others. For additional information, you should pay a visit to https://www.silence-therapeutics.com/.

Forward-Looking Statements

Sure statements manufactured in this announcement are ahead-on the lookout statements within the which means of the U.S. Personal Securities Litigation Reform Act of 1995 and other securities laws, including with regard to the Company’s medical and industrial prospective customers, regulatory approvals of the Company’s merchandise candidates, the initiation or completion of the Company’s clinical trials and the expected timing or outcomes of data studies from the Company’s scientific trials. These ahead-hunting statements are not historic information but alternatively are primarily based on the Company’s present assumptions, beliefs, expectations, estimates and projections about its field. Terms this sort of as ‘anticipates,’ ‘expects,’ ‘intends,’ ‘plans,’ ‘believes,’ ‘seeks,’ ‘estimates,’ and equivalent expressions are supposed to establish forward-wanting statements. These statements are not guarantees of potential performance and are matter to recognized and unfamiliar challenges, uncertainties, and other things, some of which are outside of the Company’s command, are tough to forecast, and could result in genuine effects to differ materially from people expressed or forecasted in the forward-looking statements, such as those people threats determined in the Company’s most recent Admission Doc and its Once-a-year Report on Variety 20-F filed with the U.S. Securities and Exchange Fee (the “SEC”) on March 17, 2022. The Firm cautions protection holders and prospective stability holders not to position undue reliance on these forward-on the lookout statements, which replicate the see of the Business only as of the day of this announcement. The forward-hunting statements made in this announcement relate only to activities as of the day on which the statements are created. The Enterprise will not undertake any obligation to launch publicly any revisions or updates to these ahead-hunting statements to mirror events, situation, or unanticipated events occurring after the day of this announcement except as necessary by law or by any appropriate regulatory authority.

Contacts

Enquiries:
Silence Therapeutics plc
Gem Hopkins, Head of IR and Company Communications

+1 (646) 637-3208

[email protected]

Media Relations
MKC Approaches
Mary Conway

+1 (516) 606-6545

[email protected]

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